本书为毒理学医学类百科全书，主要包含了毒理学的重要概念，如计量效应、作用机制、试验程序、靶位等，还收集了与毒理学相关的历史、法律、条例、数据库。对毒理学家会相当有用，同时也适用于医学、法律、科学工作者查阅。
本书是在原版Encyclopedia of Toxicology(2nd edn)的基础上对词条进行的分类重排。编成三卷，分别为精选卷、拓展卷与社科管理卷，更加适合国内读者阅读。本书涵盖了毒理学研究的各个领域，从基础到前沿，甚至一些尚存争议的问题也包含其中。
第二版百科全书汇集了392作者提供的1057条目录，而**版只包括200名作者提供的749条目录。实际上，**版中所有条目的内容在第二版中都得到了充实，而某些条目则完全进行了更新。在第二版中新出现的308个条目中，包括鸟类生态毒理学、基准剂量、杀虫剂、计算机毒理学、致癌效力因素、代谢组学、化学事件、蒙地卡罗分析、非致死性化学武器、无脊椎动物生态毒理学、**滥用、癌症化疗因子和消费产品等等。许多针对特殊化学物的条目都是全新的，而书中搜录的国际组织也得到了很大的扩展。某些条目罗列了许多**的毒物中毒相关事件：如美国拉夫运河事

Aberrations of Chromosomes（染色体畸变，染色体异常）see Chromosome Aberrations
Absorption（吸收）Jules Brodeur and Robert Tardif
Acceptable Daily Intake（ADI）（每日允许摄入量）Jaya Chilakapati and Harihara M Mehendale
Aggregate Exposures（累积照射）Jeffrey H Driver
Ames Test（埃姆斯试验）Robin C Guy
Analytical Toxicology（分析毒理学）Shayne C Gad
Aneuploidy（非整倍性）David A Eastrnond
Animal Models（动物模型）Shayne C Gad
Aquatic Ecotoxicology（水域生态毒理学、水域生态毒物学）see EcotoxicologyAquatic
Aquatic Toxicity Testing（水生毒性试验）see Toxicity Testing，Aquatic
Avian Ecotoxicology（鸟类生态毒理学）see Ecotoxicology，Avian
Behavioral Toxicity Testing（行为中毒试验、行为毒性试验）see Toxicity Testing Behavioral
Behavioral Toxicology（行为毒理学）Deborah A Cory-Slechta
Benchmark Dose（基准剂量）Qiyu Jay Zhao
Biological Exposure Index（生物照射）Alan J Weinrich
Biomarkers，Environmental（环境生物标记），Lee R Shugart
Biomarkers，Human Health（人类健康生物标记）Rogene F Henderson
Biotrans{ormation（生物转化）Tanya C McCarthy and Christopher J Sinai
Carcinogen-DNA Adduct Formation and DNA Repair（致癌原一DNA加合物形成与DNA修复）Ainsley Weston andMiriam C Poirier
Carcinogenesis（致癌作用）David E Malarkey and Robert R Maronpot
Carcinogenicity Toxicity Testing（致癌毒性试验）see Toxicity Testing Carcinog-enesis
Chemical-Specific Adjustment Factor（CSAF）（化学特异性调节因子）Bette Meek
Chromosome Aberrations（染色体畸变、染色体异常）Antone L Brooks
Combustion Toxicology（燃烧毒理学）Barbara C Levin and Erica D Kul igowski
Common Mechanism of Toxicity（主要毒性机理）Beth Mileson
Computational Toxicology（计算机毒理学）S Satheesh Anand and Harihara M Meh-endale
Cumulative Risk Assessment（累积危险评价）Jeffrey H Driver
Deoxyribonucleic Acid（脱氧核糖核酸）see Aneuploidy；Carcinogen-DNA AdductFormation and DNA Repair；Chromosome Aberrations；DNA Phosphoramidites；Genetic Toxicology；Genomics．Toxicogenomics
Dernlal Toxicity Testing（皮肤毒性试验）see Toxicity Testing，Dermal
Development Toxicity Testing（发育毒性试验）see Toxicity Testing，Developmental
Developmental Toxicology（发育毒理学）Calvin C Willhite and Philip E Mirkes
DNA（脱氧核糖核酸）see Aneuploidy；Carcinogen-DNA Adduct Formation and
DNA Repair；Chromosome Aberrations；DNA Phosphoramidites；Genetic To-
xicology；Genonlics，Toxicogenomics；Molecular Toxicology～Recombinant DNA
Technology Toxicity Testing．Mutagenicity
DNA Adduct（DNA加合物）see Carcinogen-DNA Adduct Formation and DNA Repair
DNA Phosphoramidites（DNA亚磷酰胺）Sang-Tae Kim
DNA Repair（DNA修复）see Carcinogen-DNA Adduct Formation and DNA Repair
Dominant Lethal Tests（显性致死试验）Samantha E Gad
Dose-Response Relationship（剂量效应关系）Samantha E Gad
Ecotoxicology（生态毒理学、生态毒物学）Chris Theodorakis
Ecotoxicology，Aquatic（水域生态毒理学）Yuan Zhao and Michael C Newman
Ecotoxicology，Avian（-g类生态毒理学）Pierre Mineau1
Ecotoxicology，Genetic（遗传生态毒理学）Wendy L Rose and Susan L Anderson
Ecotoxicology，Invertebrate（无脊椎动物生态毒理学）Pawel J Migula
Ecotoxicology，Terrestrial（陆地生物生态毒理学）Anne Fairbrother and Bruce Hope
Ecotoxicology，Wildlife（野生动植物生态毒理学）Richard S Halbrook
Environmental Hormone Disruptors（环境激素破坏剂）Lorenz Rhomberg and MaraSeeley
Environmental Toxicology（环境毒理学）Chris Theodorakis
Exposure（暴露）Gary Whitmyre and Sam Kacew
Exposure Assessment[（危害）暴露评估]Gary Whitmyre and Jeffrey H Driver
Exposure Criteria（暴露标准）Andrew Maier
Eye Irritancy Testing（眼球刺激试验）Samantha E Gad
Food Safety and Toxicology（食品**与毒理学）Michael Bolger and Clark D Carr_ington
Foreign Body Response（异物反应）Shayne C Gad
Forensic Toxicology（法医毒理学）Felix K Adatsi
Genetic Ecotoxicology（遗传生态毒理学）see Eeotoxicology，Genetic
Genetic Toxicology（遗传毒理学）Joseph R Landolph
Genomics，Toxicogenomics（基因组、毒物基因组）Kartik Shankar and Harihara M Mehendale
GOOd Clinical Practice（GcP）（**临床试验管理规范）Sharmilee P Sawant and Harihara M Mehendale
Good LaboratorY Practices（GLP）（良好实验室管理规范）Robin C Guy
Hormesis（毒物刺激作用）Elyisha A Hanniman and Christopher J Sinai
Hormone Disruptors（激素破坏剂）see Environmental Hormone Disruptors
Host-Mediated Assay（宿主间介试验）David A Eastmond
Hypersensitivity，Delayed Type（迟发型超敏反应）Leigh Ann Burns-Naas
Immediately Dangerous to Life or Health（IDLH）Values（即刻性损伤或致死浓度） Alan J Weinrich
Inhalation Testing（吸入试验）see Toxicity Testing，Inhalation
Interactions（相互作用）see Interactive Toxicity
Interactive Toxicity（相互作用毒性）S Satheesh Anand and Harihara M Mehendale
Irritation Testing（刺激试验）see Toxicity Testing，Irritation
LD50／LCs0（Lethal Dosage 50／Lethal Concentration 50）（半数致死剂量）Shayne C Gad
Lethal，Dosage Or Concentration（致死剂量／浓度）see LD50／LC50（Lethal Dosage
50／Lethal Concentration 50）
Levels of Effect in Toxicological Assessment（毒物效应评价水平）Michael Dourson
Lowest-Observed～Adverse-Effect Level（观察到副作用的*小剂量）see Levels of
Effect in Toxicological Assessment
Lowest-Observed-Effect Level（观察到作用的*小剂量，*低作用水平）see Leve-
Is of Effect in Toxicological Assessment
Margin of Exposure（MOE）（暴露界限）Udayan M Apte and Harihara M Mehendale
Maximum Allowable Concentration（MAC）（*高容许浓度）Shayne C Gad
Maximum T01erated Dose（MTD）（*大耐受剂量）Shayne C Gad
Mechanisms of Toxicity（毒性机制）Sanjay Chanda and Harihara M Mehendale
Mode of Action（作用方式）Lynne Haber
Models（模型）see Animal Models
Modifying Factors of Toxicity（毒性修饰因子）Frank C Lu and Sam Kacew
M01ecular Toxic010gy_Recombinant DNA Technology（分子毒理学一重组DNA技术）
Evan A Thackaberry
Mouse Lymphoma Assay（小鼠淋巴瘤测定）Robin C Guy
Neoplasia（瘤形成）see Carcinogenesis
Neurotoxicity（神经毒性）Peter S Spencer and Pamela J Lein
Nonionizing Radiation（非电离辐射）see Radiation Toxicology，Ionizing and Non-
ionizing
No-Observed-Adverse-Effect Level（未观察到的副作用水平）see Levels of Effect
in Toxicological Assessment
No-Observed-ElfeCt Level（未观察到的效应水平）see Levels of Effect in Toxicol-
ogical Assessment
Occupational Exposure Limits（职业性暴露极限）Andrew Maier
Occupational Toxicology（职业毒理学）Elizabeth V Wattenberg3
Ototoxicity（耳毒性）Michael J Sullivan
PharmacokinetiCS／Toxicokinetics（**代谢动力学／毒物代谢动力学）Robert Tardif
and Jules Brodeur
Pharmacology and Safety（**药理学）see Safety Pharmacology（拓展卷）
Radiation Toxicology，Ionizing and Nonionizing（电离辐射与非电离辐射毒理学）
Bobby R Scott and Raymond A Guilmette
Recombinant DNA（重组DNA）see Molecular Toxicology-Recombinant DNA Tee-
hnology
Safety Testing，Clinical Studies（临床研究**试验）Alessandra Pagnoni366
Sensitivity Analysis（灵敏度分析）Virginia Lau
Sensitization Testing（敏感试验、致敏试验）see Toxicity Testing，Sensitization
Short-Term Exposure Limit（短期暴露限度）see Occupational Exposure Limits
Subchronic Toxicity（亚慢性毒性）see Toxicity，Subchronic
Teratology（畸形学）see Developmental Toxicology
Teratology Testing（致畸实验）see Toxicity Testing，Developmental
Terrestrial Ecotoxicology（陆地生态毒理学）see Ecotoxicology，Terrestrial
Threshold Limit Value（阈限值）see Occupational Exposure Limits
Toxicity Testing，Alternatives（选择性毒性试验）Shayne C Gad
Toxicity Testing，Aquatic（水域毒性试验）Shayne C Gad
Toxicity Testing，Behavioral（行为毒性试验）Samantha E Gad
Toxicity Testing，Carcinogenesis（致癌毒性试验）Shayne O Gad
Toxicity Testing，Dermal（皮肤毒性试验）Samantha E Gad and Shayne C Gad
Toxicity Testing，Developmental（发育毒性试验）Rochelle W Tyl
Toxicity Testing，Inhalation（吸人毒性试验）Samantha E Gad and Shayne C Gad
Toxicity Testing，Irritation（刺激毒性试验）Pertti J Hakkinen
Toxicity Testing，Modeling（模型化毒性试验）Charles A Pittinger，Andrew Worth，
Joanna Jaworska and Joanne Shatkin
Toxicity Testing，Mutagenicity（致突变毒性试验）Robin C Guy435
Toxicity Testing，'Read Across Analysis'[识读交叉分析（毒性试验）]Pertti J
Hakkinen
Toxicity Testing，Reproductive（生殖毒性试验）Rochelle W Tyl
Toxicity Testing，Sensitization（致敏毒性试验）Rob in C Guy
Toxicity Testing，Validation（毒性试验验证）Leon H Bruner，G J Carr，M Chamb-
erlain and R D Curren
Toxicity，Acute（急性毒性）Donald J Ecobichon
Toxicity，Chronic（长期毒性）Donald J Ecobichon
Toxicity，Subchronic（亚慢性毒性）Donald J Ecobichon
Toxicokinetics（毒物代谢动力学）see Pharmacokinetics／Toxicokinetics
Toxicology（毒理学）Gabriel L Plaa
Toxicology，Intuitive（直觉毒理学）Pertti J Hakkinen
Uncertainty Analysis（不确定检验）Virginia Lau
Uncertainty Factors（不确定系数）Michael Dourson
Validation of Toxicity Testing（毒性试验验证）see Toxicity Testing，Validation
Veterinary Toxicology（兽医毒理学）Wilson K Rumbeiha and Frederick W Oehme
Virtually Safe Dose（VSD）（实际**剂量）Stephen M DiZio
拓展卷目录
社科管理卷目录
未收录词条

本书为毒理学医学类百科全书，主要包含了毒理学的重要概念，如计量效应、作用机制、试验程序、靶位等，还收集了与毒理学相关的历史、法律、条例、数据库。对毒理学家会相当有用，同时也适用于医学、法律、科学工作者查阅。