2001年8月,教育部制定并下发《关于加强高等学校本科教学工作提高教学质量的若干意见》(教高[2001]4号),指出:按照“教育面向现代化、面向世界、面向未来”的要求,为适应经济全球化和科技革命的挑战,本科教育要创造条件使用英语等外语进行公共课和专业课教学。对
高新技术领域的生物技术、信息技术等专业,更要先行一步,力争三年内,外语教学课程达到所开课程的5%~l0%。2005年1月,又印发了《关于进一步加强高等学校本科教学工作的若干意见》(教高[2005]1号),指出:高等学校要全面推广和使用大学英语教学改革的成果,要提高双语教学课程的质量,继续扩大双语教学课程的数量。要加强教材建设,确保高质量教材进课堂。
双语教育是提高学生英语水平的一个途径,尽管我国高等医学院校双语教学探索已有若干
年,但教材的跟进始终显得滞后。没有合适的教材是目前双语教学面临的困难之一。2006年初,为推进双语教学的发展,经全国高等医药教材建设研究会和卫生部教材办公室审议,决定根据**、地方和学生未来发展的需要,组织国内专家结合双语教学的经验,编写出版一套适应当前双语教学现状的教材。
此套教材的特点在于:

Chapter 1 The Science of Drug Therapy
EVALUATION OF THE EVIDENCE
Clinical Trials
Observational Studies
PATIENT-CENTERED THERAPEUTICS
DETERMINANTS OF INTERINDIVIDUAL VARIATION IN RESPONSE TO DRUGS
Disease-Induced Alterations in Pharmacokinetics
INTERACTIONS BETWEEN DRUGS
Pharmacokinetic Interactions Caused by Diminished Drug Delivery to the Site of Action
Pharmacokinetic Interactions That Increase Drug Delivery to the Site of Action
Pharmacodynamic Interactions
GENETIC DETERMINANTS OF THE RESPONSE TO DRUGS
THE PHARMACODYNAMIC CHARACTERISTICS OF A DRUG THAT DETERMINE
ITS USE IN THERAPY
Pharmacodynamic Variability
The Therapeutic Index
ADVERSE DRUG REACTIONS AND DRUG TOXICITY
THERAPEUTIC DRUG MONITORING
Intravenous Administration of Drugs
DRUG DEVELOPMENT

Chapter 2 Pharmacokinetics
PHYSICOCHEMICAL FACTORS IN TRANSFER OF DRUGS ACROSS MEMBRANES
Cell Membranes
Passive Membrane Transport
Carrier-Mediated Membrane Transport
DRUG ABSORPTION, BIOAVAILABILITY, AND ROUTES OF ADMINISTRATION
Oral (Enteral) versus Parenteral Administration
Oral Ingestion
Transdermal Absorption
Rectal Administration
Parenteral Injection
Pulmonary Absorption
Topical Application
Novel Methods of Drug Delivery
Bioequivalence
DISTRIBUTION OF DRUGS
Plasma Proteins
Tissue Binding
Redistribution
Central Nervous System and Cerebrospinal Fluid
Placental Transfer of Drugs
EXCRETION OF DRUGS
Renal Excretion
Biliary and Fecal Excretion
Excretion by Other Routes
METABOLISM OF DRUGS
The Phases of Drug Metabolism
Sites of Drug Metabolism
The Role of Xenobiotic Metabolism in the Safe and Effective Use of Drugs
CLINICAL PHARMACOKINETICS
Clearance
Distribution
Half-Life
Steady State
Extent and Rate of Bioavailability
Nonlinear Pharmacokinetics
DESIGN AND OPTIMIZATION OF DOSAGE REGIMENS
Maintenance Dose
Dosing Interval for Intermittent Dosage
Loading Dose
Individualizing Dosage
Therapeutic Drug Monitoring

Chapter 3 Pharmaeodynamies
MECHANISMS OF DRUG ACTION AND THE RELATIONSHIP BETWEEN
DRUG CONCENTRATION AND EFFECT
Mechanisms of Drug Action
Drug Receptors
Receptors for Physiological Regulatory Molecules
Regulation of Receptors
Classification of Receptors and Drug Effects
Actions of Drugs Not Mediated by Receptors
QUANTITATIQN OF DRUG-RECEPTOR INTERACTIONS AND EFFECTS
Receptor Pharmacology
Potency and Relative Efficacy

Chapter 4 Pharmacogenetics
IMPORTANCE OF PHARMACOGENETICS TO VARIABILITY IN DRUG RESPONSE
GENOMIC BASIS OF PHARMACOGENETICS
Phenotype-Driven Terminology
Types of Genetic Variants
Ethnic Diversity
PHARMACOGENETIC STUDY DESIGN CONSIDERATIONS
Pharmacogenetic Measures
Candidate Gene versus Genome-Wide Approaches
Functional Studies of Polymorphisms
Pharmacogenetic Phenotypes
Pharmacogenetics and Drug Development
Pharmacogenetics in Clinical Practice

Chapter 5 Overview of the Autonomic and Somatic Motor Nervous Systems
INTRODUCTION
NEUROTRANSMISSION AND THEIR RECEPTORS
Cholinergic Transmission
Adrenergic Transmission
PHYSIOLOGIC FUNCTION OF THE AUTONOMIC AND SOMATIC AND SOMATIC
MOTOR NERVOUS SYSTEMS
EFFECT AND CLASSIFICATION OF DRUGS ON THE AUTONOMIC AND SOMATIC
MOTOR NERVOUS SYSTERMS

Chapter 6 Cholinergic Receptor Agonists Agents
ACETYLCHOLINE AND ITS MUSCARINIC RECEPTOR TARGET
Pharmacological Properties
CHOLINOMIMETIC CHOLINE ESTERS AND NATURAL ALKALOIDS
Pharmacological Properties
Therapeutic Uses
Precautions, Toxicity, and Contraindications
STIMULATING GANGLIONIC DRUGS
Nicotine

Chapter 7 Anticholinesterase Agents and Reactivators
ANTICHOLINES TERASE DRUGS
Mechanism of Action of AChE Inhibitors
Pharmacological Properties
Absorption, Fate, and Excretion
Toxicology
CHOLINESTERASE REACTIVATORS
Pharmacology, Toxicology, and Disposition
THERAPEUTIC USES
Available Therapeutic Agents
Paralytic Ileus and Atony of the Urinary Bladder
Glaucoma and Other Ophthalmologic Indications
Myasthenia Gravis
Alzheimer's Disease

Chapter 8 Cholinergic Receptor Antagonists Agents ( I ) - Muscarinic Receptor Antagonists Agents
MECHANISM OF ACTION
PHARMACOLOGICAL PROPERTIES: THE PROTOTYPICAL ALKALOIDS ATROPINE
AND SCOPOLAMINE
Central Nervous System
Ganglia and Autonomic Nerves
Eye
Cardiovascular System
Respiratory Tract
Gastrointestinal Tract
Other Smooth Muscle
Sweat Glands and Temperature
PHARMACOLOGIC PROPERTIES: THE QUATERNARY DERIVATIVES
IPRATROPIUM AND TIOTROPIUM
Absorption, Fate, and Excretion of Muscarinic Antagonists
Therapeutic Uses of Muscarinic Receptor Antagonists
POISONING BY MUSCARINIC RECEPTOR ANTAGONISTS AND OTHER DRUGS
WITH ANTICHOLINERGIC PROPERTIES

Chapter 9 Cholinergic Receptor Antagonists Agents ( H ) - Neuromuscular and Ganglionic Blocking Drugs
NEUROMUSCULAR BLOCKING AGENTS
Classification and Chemical Properties of Neuromuscular Blocking Agents
Pharmacological Properties
Absorption, Fate, and Excretion
Therapeutic Uses
GANGLIONIC BLOCKING DRUGS
Pharmacological Properties
Absorption, Fate, and Excretion
Untoward Responses and Severe Reactions
Therapeutic Uses

Chapter 10 Adrenergic Agonists
STRUCTURE-FUNCTION RELATIONSHIP AND CLASSIFICATION
Classification of Sympathomimetic Drugs
Physiological Basis of Adrenergic Receptor Function
……
Chapter11 Adrenergic Receptor Antagoinists
Chapter12 Drugs Acting of the Central Nervous System
Chapter13 General Anesthetics
Chapter14 Local Anesthetics
Chapter15 Hypnotics and Sedatives
Chapter16 Pharmacotherapy of the Epilepsies
Chapter17 Treatment of Central Nervous System Degenerative Disorders
Chapter18 Antipsychoses Agents
Chapter19 Opioid Analgesics
Chapter20 Analgesic-Antipyretic and Antiinflammatory Agents
Chapter21 Antiarrhythmic Drugs
Chapter22 Renin and Angiotensin
Chapter23 Diuretics
Chapter24 Drugs Used for Therapy of Hypertension
Chapter25 Pharmacotherapy of Congestive Heart Failure
Chapter26 Treatment of Myocardial Ischemia
Chapter27 Drug for Therapy of Dyslipidemia and Antiatherogenic
Chapter28 Drugs Acting on the Blood and the Blood-Forming Organs
Chapter29 Drugs that Effect Self-Activity
Chapter30 Pharmacotherapy of Asthma
Chapter31 Drugs Affecting Gastrointestinal Function
Chapter32 Drugs Acting on the Uterus Smooth Muscle
Chapter33 Gonadal Hormone and Anticoncipiens
Chapter34 Adrenocorticosteroids
Chapter35 Thyroid and Antithyroid Drugs
Chapter36 Insulin Oral Hypoglycemic Agents and the Pharmacology of the Endocrine Pancreas
Chapter37 Overviews of Antimicrobial Therapy
Chapter38 B-Lactam Antibiotics
Chapter39 Macrolides Clindamycin and Polypeptide Antibiotics
Chapter40 Aminoglycosides
Chapter41 Tetracyclines chloramphenicol
Chapter42 Artificial Synthetic Antibacterial Drugs
Chapter43 Antiviral Agents and Antifungal Agents
Chapter44 Chemotherapy of Tuberculosis Mycobacterium Avium Complex Disease and Leprosy
Chapter45 Chemotherapy of Parasitic Infections
Chapter46 Antineoplastic Agents
Chapter47 Immunosuppressants and Immunostimulants
Index
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